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A) A UMAP plot is generated from <t>the</t> <t>single-cell</t> data, processed by the STAR-MAPS framework. Cells are colored by dissected brain region. B) The same UMAP, colored by cell-type label from the initial description of the dataset. C) A heatmap showing the degree of enrichment for 185 ASD-associated genes in the cells from Panels A and B, in data corrected for sample, batch, and developmental stage. Shade represents the magnitude of positive odds ratios; stars represent the P-value.
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Regional heterogeneity of Bnc2 mRNA abundance in the mouse brain Quantitative analysis of Bnc2 expression levels (normalized transcripts per million, nTPM) across distinct brain regions, sourced from The protein atlas bulk RNA-seq dataset. Anatomical structures are color-coded and grouped into major divisions: cerebral cortex, olfactory bulb, hippocampal formation, amygdala, basal ganglia, thalamus, hypothalamus, midbrain, pons and medulla, cerebellum, and corpus callosum (white matter). Bars represent the mean nTPM value, and dots indicate individual sample replicates, demonstrating expression variability within each region. Data are presented as mean ± SD.

Journal: iScience

Article Title: BNC2 as a putative transcriptional coordinator linking energy state to neural circuits

doi: 10.1016/j.isci.2026.115733

Figure Lengend Snippet: Regional heterogeneity of Bnc2 mRNA abundance in the mouse brain Quantitative analysis of Bnc2 expression levels (normalized transcripts per million, nTPM) across distinct brain regions, sourced from The protein atlas bulk RNA-seq dataset. Anatomical structures are color-coded and grouped into major divisions: cerebral cortex, olfactory bulb, hippocampal formation, amygdala, basal ganglia, thalamus, hypothalamus, midbrain, pons and medulla, cerebellum, and corpus callosum (white matter). Bars represent the mean nTPM value, and dots indicate individual sample replicates, demonstrating expression variability within each region. Data are presented as mean ± SD.

Article Snippet: We thank the Allen Institute for Brain Science for providing open access to the Mouse Whole-Brain Transcriptomic Cell Type Atlas (MERFISH, Allen Brain Cell Atlas; knowledge.brain-map.org ), and the Human Protein Atlas consortium for publicly available bulk RNA-seq data ( www.proteinatlas.org ).

Techniques: Expressing, RNA Sequencing, Olfactory

A) A UMAP plot is generated from the single-cell data, processed by the STAR-MAPS framework. Cells are colored by dissected brain region. B) The same UMAP, colored by cell-type label from the initial description of the dataset. C) A heatmap showing the degree of enrichment for 185 ASD-associated genes in the cells from Panels A and B, in data corrected for sample, batch, and developmental stage. Shade represents the magnitude of positive odds ratios; stars represent the P-value.

Journal: bioRxiv

Article Title: Spatiotemporal analysis of autism gene enrichment implicates cortex, thalamus, and hypothalamus

doi: 10.64898/2026.05.14.724487

Figure Lengend Snippet: A) A UMAP plot is generated from the single-cell data, processed by the STAR-MAPS framework. Cells are colored by dissected brain region. B) The same UMAP, colored by cell-type label from the initial description of the dataset. C) A heatmap showing the degree of enrichment for 185 ASD-associated genes in the cells from Panels A and B, in data corrected for sample, batch, and developmental stage. Shade represents the magnitude of positive odds ratios; stars represent the P-value.

Article Snippet: Bhaduri et al . also describes 10X Genomics Chromium single-cell RNA-seq data but from eleven individual brains in the second trimester (12-23 PCW).

Techniques: Generated, Single Cell